Gaia Herbs | plant intelligence

Wild Lettuce


This plant is related to common lettuce; Lactuca sativa, but as it’s common name suggest is a wild species. Wild lettuce is cultivated in Austria, France, Germany and Scotland and can be collected from the wild across the southern United States where it has become naturalized, and from Northern and Eastern Europe. Opium Lettuce, another common names for Wild Lettuce harkens to the milky latex substance that exudes when the plant is broken, which was prepared as a substitute for Opium in the 1900’s by physicians. A preparation from wild lettuce was described in the United States Dispensatory of 1898. Although the prepared latex resin from the plant is purported to have some of the same properties as opium, the effects are much more mild and it is not chemically related to any of the opiate drugs.


Wild lettuce has been used historically to support nerves and promote restful sleep.* It is a bitter plant and therefore has some historical use for supporting digestion. The chemical constituents found in Wild Lettuce in the milky latex or Lactucarium have been studied for various properties relating to the central nervous system and pain centers in the brain.* Lactucin one of the chemicals is classified as a Sesquiterpene Lactone and the research centers on its action as an adenosine receptor agonist.*

Uses of Wild Lettuce


    This information in our Herbal Reference Guide is intended only as a general reference for further exploration, and is not a replacement for professional health advice. This content does not provide dosage information, format recommendations, toxicity levels, or possible interactions with prescription drugs. Accordingly, this information should be used only under the direct supervision of a qualified health practitioner such as a naturopathic physician.

    Active Constituents

    Hyoscyamine, Germanicol, Lactucerin, Lactucerols, Lactucic Acid, Lactucin, Lactupicrin, Malic Acid, Mannitol, Oxalic Acid, Squalene, Taraxasterol

    Parts Used

    • Herb

    Important precautions

    Not for use during pregnancy. If you have a medical condition or take pharmaceutical drugs please consult your doctor prior to use.

    Additional Resources

    Ecologically Harvested is a term that describes all herbs sold by Gaia Herbs that are not Certified Organic. Ecologically Harvested herbs include herbs that are harvested in their natural habitat, (i.e., wild harvested) according to specific guidelines for harvesting these herbs (i.e., away from roads and industry, as well as guidelines to avoid overharvesting). Our term, Ecologically Harvested, also includes herbs that are grown in managed woodland areas, fields designated for specific herbs, and herbs that are grown by indigenous growers, such as Kava Kava. All Ecologically Harvested herbs pass pesticide and heavy metal testing as well as microbial testing, prior to release.