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Search Terms: Silybum marianum produced 81 Entries
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25
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Silybum marianum - (milk thistle)
- 71
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A regioisomer of the known flavanolignan (-)-silandrin (3a), named (-) -isosilandrin (8a), was isolated from the fruits of a white-flowered variant of Silybum marianum L. populated in Hungary. Its structure was established both by spectroscopic methods and total synthesis.
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Samu 2004
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Investigations into the stability of tincture preparations of milk thistle fruit [ Silybum marianum L. Gaertn. (Asteraceae)] have led to the characterization of a new flavonolignan called silyamandin (1).
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MacKinnon 2007
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A comprehensive metabolomic profiling of Silybum marianum (L.) Gaernt cell cultures elicited with yeast extract or methyl jasmonate for the production of silymarin was carried out using one- and two-dimensional nuclear magnetic resonance spectroscopy.
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S�nchez-Sampedro 2007
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Formation of flavanolignane in the white-flowered variety (Szibilla) of Silybum marianum in relation to fruit development was studied. [Article in Hungarian]
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B�la 2007
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Silybum marianum may have a protective effect in the inflammatory response to chronic hepatitis C, but no role as an antiviral agent.
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Torres 2004
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Study on substantiating the potential use of flavolignans of Silybum marianum (L.) Gaertn. to create a new fat product-butter fortified by an "Liguid extract Silybum marianum (L.) Gaertn." are discussed. [Article in Russian]
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Spiridonov 2005
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In vitro evaluation and pharmacokinetics in dogs revealed that solid dispersion pellets containing Silybum marianum extract prepared by fluid-bed coating showed favorable in vitro characteristics and enhanced oral bioavailability.
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Sun 2008
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Silymarin (Silybum marianum [L.] Gaertn.) is a promising agent for cancer prevention, adjuvant cancer treatment, and reduction of iatrogenic toxicity.
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Sagar 2007
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Silybin and 2,3-dehydrosilybin (1-50 micromol/l), flavonolignan components of Silybum marianum, were tested for their ability to moderate UVA-induced damage in HaCaT keratinocytes which showed that these flavonolignans suppress UVA-caused oxidative stress.
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Svobodov� 2007
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Study on the complementary and alternative medicine use by 76 patients chronically infected with hepatitis C virus shows that the most commonly used herb was Silybum marianum (milk thistle), reported by 10 of 76 patients (13.2%).
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White 2007
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The protective potential of Silibinin, the most active hepatoprotective constituent of Silybum marianum (milk thistle)�s seed, in liver transplantation injury was assessed and showed that silibinin protected the liver from cold preservation/warm reperfusion damages.
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Ligeret 2008
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The effect of silibinin, a component of Silybum marianum, on cellular differentiation was investigated in the leukemia HL-60 cell culture system. Silibinin enhanced protein kinase C (PKC) activity and increased protein levels of both PKCalpha and PKCbeta in 1,25-(OH)(2)D(3)-treated HL-60 cells.
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Kang 2001
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Flavonoids of milk thistle, Silybum marianum fed to rats, reduced toxicity of T-2 toxin and was accompanied by reduction of a degree of change of activity of lysosomal enzymes and microsomal xenobiotic metabolizing enzymes.
[Article in Russian]
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Kravchenko 2000
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A new method of bioactivity-directed fractionation, based on multidrug resistant pump (MDR) inhibition in Staphylococcus aureus, was demonstrated. A natural flavonolignan, silybin (8) from Silybum marianum, was also shown to be a bacterial MDR pump inhibitor.
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Stermitz 2000
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Iran grown Silybum marianum, Matricaria chamomilla, Calendula officinalis and Cichorium intybus extracted with 70% ethanol were found
to enhance the proliferation of lymphocytes after stimulation with the allogenic cells.
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Amirghofran 2000
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Silybum marianum, inhibited in vitro the copper-induced oxidation of human LDL in a concentration-dependent manner. Silybin, a main flavonolignan of silymarin, appeared to be responsible for this LDL antioxidant effect.
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Skottova 1999
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Silybum marianum (milk thistle) has applications in the treatment of hepatitis, fatty liver, cirrhosis, ischemic injury, and radiation toxicity. The hepatoprotective effect of Picrorhiza kurroa was found to be similar, or superior to that of Silybum.
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Luper 1998
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Process for isolation of hepatoprotective agent silymarin from the seeds of the plant Silybum marianum
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US Patent 6,309,678
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Cosmetic preparations useful for opposing skin aging containing an extract of the fruits of Silybum marianum
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US Patent 4,749,573
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Health food useful for preventing liver and biliary dysfunctions containing an alkanoyl L-carnitine and Silybum marianum extract
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US Patent 6,552,070
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Milk thistle (Silybum marianum) derivatives in the therapy of chronic hepatopathies [Article in Italian]
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De Martiis 1980
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On the pharmacology and toxicology of silymarin, an antihepatotoxic active principle from Silybum marianum (L.) Gaertn [Article in German]
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Hahn 1968
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Determination of 23 elements in Silybum marianum [Article in Hungarian]
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Szentmihalyi 1998
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Constituents of Silybum marianum and their therapeutic use [Article in Italian]
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Morelli 1978
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High-performance liquid chromatographic separation of silymarins and their determination in a raw extract of Silybum marianum Gaertn [Article in German]
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Tittel 1977
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